Active constituents
The leaves of bacopa contain saponins, including the bacosides,2 3
4 which are thought responsible for the therapeutic properties of the herb.
In animal studies, both purified bacosides and extracts of bacopa standardized for bacosides
have been found to enhance several aspects of mental function and learning
ability.5 6 7 Additional brain effects of bacopa demonstrated
in animal research include reduction of both anxiety and depression.8 9
Biochemically, these nervous-system effects have been attributed to an enhancement of the
effects of the neurotransmitters acetylcholine and,10 11 possibly,
serotonin or GABA (gamma aminobutyric acid).12 13
Bacopa extracts also appear to have significant antioxidant activity in the
brain,14 and other effects that may help protect brain cells.15
Animal research has also reported that bacopa extracts can relax the muscles that control
the blood vessels, the intestine, and the airways of the respiratory system,16
17 18 19 and can help both prevent and heal ulcers in
the stomach.20
1. [No author listed]. The Wealth of India: Raw Materials. II-B.
New Delhi: Publications and Information Directorate, CSIR, 1950:2–3.
2. Chatterji N, Rastorgi RP, Dhar ML. Chemical examination of Bacopa
monniera Wettst. Part I: isolation of chemical constituents. Indian J Chem
1963;1:212.
3. Rastogi S, Pal R, Kulshreshtha DK. Bacoside A3—a triterpenoid
saponin from Bacopa monniera. Phytochemistry 1994;36:133–7.
4. Jain P, Kulshreshtha DK. Bacoside A1, a minor saponin from Bacopa
monniera. Phytochemistry 1993;33:449–51.
5. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the
Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol
1997;29:S359–S365.
6. Singh HK, Rastogi RP, Srimal RC, Dhawan BN. Effect of bacosides A and
B on avoidance responses in rats. Phytother Res 1988;2:70–5.
7. Singh HK, Dhawan BN. Effect of Bacopa monniera Linn. (brahmi) extract
on avoidance responses in rat. J Ethnopharmacol 1982;5:205–14.
8. Bhattacharya SK, Ghosal S. Anxiolytic activity of a standardized
extract of Bacopa monniera—an experimental study. Phytomedicine
1998;5:77–82.
9. Sairam K, Dorababu M, Goel RK, Bhattacharya SK. Antidepressant
activity of standardized extract of Bacopa monniera in experimental models of depression in
rats. Phytomedicine 2002;9:207–11.
10. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract
of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.
Psychopharmacology 2001;156:481–4.
11. Bhattacharya SK, Kumar A, Ghosal S. Effect of Bacopa monniera on
animal models of Alzheimer's disease and perturbed central cholinergic markers of cognition in
rats. In: Siva Sanka DV, ed. Molecular Aspects of Asian Medicine. New York: PJD
Publications, 2000.
12. Ganguly GK, Malhtora CL. Some neuropharmacological and behavioral
effects of an activefraction from Herpestis monniera Linn (Brahmi). Indian J Physiol
Pharmacol 1967;11:33–43.
13. Dey PK, Datta C. Effect of psychotropic phytochemicals on cerebral
amino acid level. Indian J Exp Biol 1966; 4:216–8.
14. Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S. Antioxidant
activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother
Res 2000;14:174–9.
15. Russo A, Borrelli F, Campisi A, et al. Nitric oxide-related toxicity
in cultured astrocytes: effect of Bacopa monniera. Life Sci
2003;73:1517–26.
16. Dar A, Channa S. Bronchodilatory and cardiovascular effects of an
ethanol extract of Bacopa monniera in anaesthetized rats. Phytomedicine
1997;4:319–23.
17. Dar A, Channa S. Relaxant effect of ethanol extract of Bacopa
monniera on trachea, pulmonary artery and aorta from rabbit and guinea-pig. Phytother
Res 1997;11:323–5.
18. Channa S, Dar A, Yaqoob M, et al. Broncho-vasodilatory activity of
fractions and pure constituents isolated from Bacopa monniera. J Ethnopharmacol
2003;86:27–35.
19. Dar A, Channa S. Calcium antagonistic activity of Bacopa monniera on
vascular and intestinal smooth muscles of rabbit and guinea-pig. J Ethnopharmacol
1999;66:167–74.
20. Sairam K, Rao CV, Babu MD, Goel RK. Prophylactic and curative effects
of Bacopa monniera in gastric ulcer models. Phytomedicine 2001;8:423–30.
21. [No author given]. Indian Herbal Pharmacopoeia, Volume 1.
Worli, Mumbai: Indian Drug Manufacturers Association, 1998.
22. Singh HK, Dhawan BN. Neuropsychopharmacological effects of the
Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Indian J Pharmacol
1997;29:S359–S365.
23. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract
of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects.
Psychopharmacology 2001;156:481–4.